Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Aged ≥ 18
Diagnosis of osteoarthritis in knee or hip
Numerical Rating Scale (NRS) ≥ 4 during the most painful movement in the last 24 hours
Lequesne's Functional Index (LFI) score ≥ 7
Ambulant patient

Pregnant and breastfeeding
Autoimmune disease such as rheumatoid arthritis, gout, lupus
Joint trauma, joint injury, joint infection, meniscus tear, complete loss of articular cartilage
Expectation of surgery
History of the viscous or corticosteroids injections into affected joints or oral corticosteroids within last 12 months
Allergy to one of the intervention's ingredients or NSAIDs
Peptic ulceration and upper gastrointestinal haemorrhage
High alcohol intake, inability to abstain from alcohol, substance abuse, history of addiction
Tumor, cancer
Abnormal renal or/and hepatic functions or altered blood chemistry
Use of concomitant medication able to interfere with the interventions

The Effectiveness of a Herbal Supplement in Osteoarthritis.