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Ayahuasca, Esketamine and PTSD | Clinical Trials | Clareo Health

RECRUITINGPHASE2

Ayahuasca, Esketamine and PTSD

Effects of Single Dose of Ayahuasca or Esketamine on Posttraumatic Stress Disorder: a Randomized, Double-blinded Study

NCT07317206•University of Sao Paulo

Summary

Double-blind, randomized trial comparing a single dose of oral ayahuasca or esketamine in patients with posttraumatic stress disorder.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•posttraumatic stress disorder

Exclusion Criteria

•psychiatric and other medical comorbidities

Locations (1)

Hospital das Clínicas da FMRP-USP

Ribeirão Preto, São Paulo, Brazil

Key Dates

Start Date

December 20, 2025

Primary Completion Date

June 1, 2026

Completion Date

July 1, 2026

Last Updated

January 5, 2026

Enrollment

ESTIMATED participants

Conditions

Posttraumatic Stress Disorder (PTSD)

Interventions

Ayahuasca

DRUG

Esketamine

DRUG

Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD

NCT07238192

Posttraumatic Stress Disorder (PTSD)Suicidal Ideation+1 more

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RECRUITINGPHASE2

A Study to Evaluate Effects on Sleep and Safety of RE03 in PTSD Patients With Sleep Disturbances

NCT06685965

Posttraumatic Stress Disorder (PTSD)Sleep Disturbances and Insomnia

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 5, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Ayahuasca, Esketamine and PTSD

Inclusion Criteria

Exclusion Criteria

Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD

A Study to Evaluate Effects on Sleep and Safety of RE03 in PTSD Patients With Sleep Disturbances

Treatment for PTSD and Tinnitus

Resilience Building Among Older Adults: the Heart Math Based Interventions for Posttraumatic Stress Disorder, Spirituality and Psychosocial Well-being

Integrated Health Care for PTSD

The Impact of Vocational Rehabilitation on Mentally III Veterans