Gemcitabine and Nab-Paclitaxel Combined With Iparomlimab and Tuvorilimab for Advanced Gallbladder Cancer

Exclusion Criteria

• •Severe systemic infection or uncontrolled comorbidities (e.g., heart failure, thyroid disease, psychiatric disorders); active autoimmune disease requiring medication.
• •Known allergy or intolerance to chemotherapy agents.
• •Prior antitumor therapy (chemotherapy, radiotherapy, immunotherapy) within the past year, or history of other malignancies (except cured cervical carcinoma in situ or non-melanoma skin cancer).
• •Pregnancy, lactation, or unwillingness to use contraception.
• •Participation in another clinical trial within 30 days before the first dose.
• •Unwillingness to participate or inability to provide informed consent.
• •Any other condition that, in the investigator's judgment, may affect patient safety or compliance