A Research Study to Evaluate the Efficacy and Safety of SGC001 in Patients With Anterior Wall ST-Segment Elevation Myocardial Infarction

Exclusion Criteria

• •1. History of the following cardiac conditions:
• •1. History of myocardial infarction, coronary revascularization (including percutaneous coronary intervention \[PCI\] and coronary artery bypass grafting \[CABG\], etc.);
• •2. History of cardiopulmonary resuscitation;
• •3. History of stroke;
• •4. Presence of severe cardiac structural abnormalities such as aortic dissection, and ventricular aneurysm (including new-onset ventricular aneurysm);
• •2. Patients who have received thrombolysis;
• •3. Patients with a life expectancy of less than 1 year;
• •4. Febrile infection requiring systemic treatment within 2 weeks prior to screening;
• •5. Left bundle branch block (QRS duration ≥0.12 seconds. Broad R waves in leads V5 and V6, with a notch or slurring at the top, and no preceding q wave. Broad S waves or rS patterns in leads V1 and V2. T waves in leads V5 and V6 are opposite in direction to the main QRS wave);
• •6. Cardiogenic shock or hemodynamic instability;
• •7. Concomitant severe arrhythmia (including high-degree atrioventricular block, sick sinus syndrome, sustained ventricular tachycardia, etc.) or implanted cardiac pacemaker;
• •8. Definitive diagnosis of acute cardiac failure (Killip classification ≥ III; for details on Killip classification, see Appendix);
• •9. Unable to undergo cardiac magnetic resonance (CMR) imaging according to the study protocol, or known allergy to any radiocontrast agent;
• •10. Participation in other drug clinical trials and use of other investigational drugs within 3 months before receiving the study drug;
• •11. Concomitant history of the following serious diseases:
• •1. Severe hepatic or renal insufficiency (e.g., requiring dialysis);
• •2. Malignant tumor or history of malignant tumor;
• •3. Severe autoimmune disease requiring therapeutic intervention;
• •12. Men and women of childbearing potential (WOCBP) who are fertile and have plans to conceive during the study period, as well as pregnant or lactating women;