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The Effects of Chiropractic on Cancer-related Fatigue

The Effects of Chiropractic Care on Adults With Chronic Cancer-related Fatigue: a Pilot Trial

NCT07300319•Life University

Summary

The goal of this randomized controlled study is to investigate the impact of chiropractic care on CCRF (Chronic Cancer Related Fatigue) and other health-related challenges that burden cancer survivors.

Detailed Description

To our knowledge, the impact of chiropractic care on CCRF and other health-related challenges that burden cancer survivors has yet to be investigated. Because this is a pilot trial, the primary outcomes center around feasibility and include 1) randomization, 2) compliance, 3) tolerability, 4) adherence, and 5) retention in each arm. Secondary outcomes include changes in patient-reported outcomes (PROs), electrocardiography (ECG) derived heart rate variability (HRV), impedance cardiography (ICG) derived pre-ejection period (PEP), and number of completed sit-to-stands.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•18-65 years of age.
•Self-report that they have been informed by their primary health care provider that they are cancer-free (this is sometimes referred to as 'complete remission' or 'cured').
•Minimum of 3 months since the completion of their primary curative-intent cancer therapies including surgery, chemotherapy, radiotherapy, and/or immunotherapy (long-term hormone therapy permitted)
•Scores in the moderate-to-severe range (i.e., at or above the 60th percentile) on the FACIT-Fatigue scale.
•Fatigue onset was at some point during their illness/treatment \& negatively impacts their quality of life \& daily functioning.

Exclusion Criteria

•Chiropractic care within the past 2 weeks
•Taking short-acting benzodiazepines which include midazolam/Versed \& triazolam/Halcion.
•Taking GLP-1 medications
•Taking other types of prescription medications (including hormone therapy) and hasn't been on a stable dose for a minimum of 6 weeks with plans to change medications or doses during the study.
•Disorders that cause fainting during rapid postural changes (e.g., POTS, orthostatic hypotension).
•Not able to make a fist or grip objects with one or both hands
•Deaf in one or both ears (hearing aids are ok)
•Heart conditions, including pacemakers, which impact heart function
•Diagnosed with rheumatoid arthritis, osteoporosis, or medically diagnosed cervical spine instability.
•Current litigation related to a physical, health-related injury.
+1 more criteria

Locations (1)

Center for Chiropractic Research

Marietta, Georgia, United States

Key Dates

Start Date

February 1, 2026

Primary Completion Date

February 1, 2028

Completion Date

February 1, 2028

Last Updated

February 11, 2026

Enrollment

ESTIMATED participants

Conditions

CancerFatigue

Interventions

Immediate Chiropractic Care

OTHER

Delayed Chiropractic Care

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 11, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Effects of Chiropractic on Cancer-related Fatigue

Inclusion Criteria

Exclusion Criteria

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