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The Effect of Hydroxytyrosol Administration on Superoxide Dismutase, Pulsatility Index and Resistance Index of Uterine Artery Doppler and Flow-Mediated Dilatation of Brachial Artery In Mothers With Hypertension In Pregnancy | Clinical Trials | Clareo Health

ACTIVE_NOT_RECRUITINGNA

The Effect of Hydroxytyrosol Administration on Superoxide Dismutase, Pulsatility Index and Resistance Index of Uterine Artery Doppler and Flow-Mediated Dilatation of Brachial Artery In Mothers With Hypertension In Pregnancy

NCT07298759•Dr Cipto Mangunkusumo General Hospital

View on ClinicalTrials.gov

Summary

The purpose of this clinical trial is to evaluate the effect of hydroxytyrosol 10 mg/day administered for 4 weeks in pregnant individuals with hypertension. This study will assess whether hydroxytyrosol increases serum superoxide dismutase levels, reduces uterine artery Doppler pulsatility and resistance indices, and improves brachial artery flow-mediated dilation. Participants will be randomly assigned to receive either hydroxytyrosol or a matching placebo. Both products will be visually identical to ensure blinding. Participants will take two capsules daily for 4 weeks and attend two study visits for assessments and follow-up.

Eligibility

Age

All ages

Sex

FEMALE

Healthy Volunteers

Inclusion Criteria

•1. Singleton pregnancy with a live intrauterine fetus
•2. Gestational age 24-32 weeks. Gestational age is confirmed based on:
•* Last Menstrual Period (LMP)
•* First trimester ultrasound biometry
•3. Belongs to the Hypertensive Disorders of Pregnancy group, with the following criteria:
•* Gestational hypertension and preeclampsia according to ACOG 2018 criteria
•* Chronic hypertension according to ACOG 2019 criteria
•* Superimposed preeclampsia according to ACOG 2018 criteria

Exclusion Criteria

•1. Pregnancy with infection, including chronic infections such as tuberculosis (TB), HIV, or hepatitis B
•2. Pregnancy with other complications (e.g., diabetes mellitus, heart disease, kidney disease, liver disease, malignancy, autoimmune disorders)
•3. Refusal to participate in the study

Locations (1)

Dr. Cipto Mangunkusumo National Central Public Hospital

Jakarta, Jakarta Special Capital Region, Indonesia

Key Dates

Start Date

June 11, 2025

Primary Completion Date

December 31, 2025

Completion Date

February 1, 2026

Last Updated

January 7, 2026

Enrollment

ACTUAL participants

Conditions

Hypertension in Pregnancy

Interventions

Placebo

DIETARY_SUPPLEMENT

Hydroxytyrosol

DIETARY_SUPPLEMENT

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Hypertension in PregnancyHypertension+3 more

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ACTIVE_NOT_RECRUITINGNA

Mindfulness & Mechanisms Study

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Hypertension in Pregnancy

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 7, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Effect of Hydroxytyrosol Administration on Superoxide Dismutase, Pulsatility Index and Resistance Index of Uterine Artery Doppler and Flow-Mediated Dilatation of Brachial Artery In Mothers With Hypertension In Pregnancy

Inclusion Criteria

Exclusion Criteria

Enhancing Intergenerational Health in Nigeria: Peripartum as Critical Life Stage for Cardiovascular Health

Mindfulness & Mechanisms Study

Supporting Transitions to Primary Care Among Under-resourced, Postpartum Women (STEP-UP)

Remote Patient Monitoring for Chronic Hypertension During Pregnancy (REACH)

Pulmonary Artery Doppler And Neonatal Outcome In Hypertensive Disorders Of Pregnancy

Bridging the Gap From Postpartum to Primary Care