⁶⁸Ga-FAPI PET/CT for Cardiac Fibrosis in Heart Failure

Inclusion Criteria

• •≥ 18 years old;
• •Signs and symptoms of heart failure (HF);
• •\[Preserved left ventricular ejection fraction (LVEF) (≥50%) and Evidence of structural/functional abnormality consistent with diastolic dysfunction/increased ventricular filling pressures, including elevated natriuretic peptides and Imaging diagnosis of hypertrophic cardiomyopathy and Genetic diagnosis of hypertrophic cardiomyopathy due to sarcomeric gene mutation\] OR \[Reduced LVEF (≤40%) and Imaging diagnosis of dilated cardiomyopathy: left ventricular end-diastolic diameter \>58 mm in men and \>52 mm in women, and left ventricular volume ≥75 mL/m² in men and ≥62 mL/m² in women, not explained solely by loading conditions\]
• •Recent transthoracic echocardiogram (\< 3 months);
• •Recent cardiac magnetic resonance imaging (\< 3 months).
• •Normal coronary angiogram or computed tomography coronary angiography within 6 months of enrolment