Deep Cervical LymphatIc-Venous Anastomosis for Alzheimer's Disease

Exclusion Criteria

• •Contraindications to MRI, ICG angiography, or PET.
• •Contraindications to surgery or anesthesia, such as coagulation disorders (platelet count \<100×10⁹/L, INR \>1.7).
• •Comorbid major organ dysfunction, such as reduced left ventricular ejection fraction, severe hepatic or renal insufficiency (AST or ALT \>3 times the upper limit of normal; eGFR \<30 mL/min/1.73m²).
• •Intracranial structural lesions indicated by MRI, including brain tumors, cerebral infarction, intracranial hemorrhage, aneurysms, arteriovenous malformations, hydrocephalus, etc.
• •MRI findings suggestive of significant cerebral small vessel disease features: more than one lacunar infarction in the deep white matter and periventricular regions and/or white matter hyperintensity (WMH) with a Fazekas grade \>2, or the presence of ≥4 cerebral microbleeds.
• •Other causes of dementia, such as hypothyroidism or vitamin B12 deficiency.
• •Drug/alcohol addiction.
• •Severe psychiatric illness or suicide risk.
• •Comorbid medical conditions with a life expectancy of less than 1 year.
• •Participation in another interventional trial within the past 3 months.
• •Poor compliance or judged by the investigator as unsuitable for participation.
• •Patients receiving therapy with Lecanemab or Donanemab.
• •Other conditions that the researcher deems unsuitable for participation in this study.