Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity

Exclusion Criteria

• •1. Presence of secondary obesity (e.g., endocrine disorders such as Cushing's syndrome or hypothyroidism).
• •2. Use of anti-obesity medications or participation in another weight-loss program within the past 3 months.
• •3. Diagnosed type 1 or type 2 diabetes mellitus requiring hypoglycemic drug therapy.
• •4. History of pancreatitis, severe gastrointestinal disease, or bariatric surgery.
• •5. Severe cardiovascular, hepatic, renal, or psychiatric disease that may affect participation.
• •6. Pregnant or breastfeeding women, or women planning pregnancy during the study period.
• •7. Current participation in any other clinical trial.
• •8. Any condition that, in the investigator's judgment, makes the participant unsuitable for the study.