A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Exclusion Criteria

• •1. Positive viral serology for human immunodeficiency virus (HlV), hepatitis C virus (HCV), or hepatitis B (HBV)
• •2. Immunodeficiencies, autoimmune diseases, or cancer, history of conditions predisposing to infections
• •3. History of major metabolic, dermatological, liver, kidney, hematological or other significant disorders
• •4. Clinically relevant abnormal lab results, including low blood counts, liver enzymes, or abnormal kidney function
• •5. Positive drug/alcohol tests or abnormal vital signs at screening or Day -1
• •6. Abnormal Electrocardiogram(ECG) findings
• •7. History of drug/alcohol abuse in the past 2 years
• •8. History of severe allergic reactions or hypersensitivity
• •1. Current diagnosis of other significant pulmonary disease
• •2. Significant or unstable cardiovascular diseases
• •3. Recent clinically significant infection
• •4. Inability to perform spirometry