Phase 2b, Open Label, Multisite, Randomized Crossover Study of DPP Versus 2PR

Inclusion Criteria

• •Age 16 through 39 years old (inclusive) at Screening.
• •Adults must be able and willing to provide informed consent. Adolescents (16- and 17-year-olds) will be consented according to applicable local guidelines, by obtaining participant assent and where applicable parental or guardian permission.
• •Able and willing to provide adequate locator information.
• •Able and willing to comply with all study procedures.
• •Must be post-menarche and pre-menopausal and could potentially become pregnant.
• •Sexually active, defined as having had penile-vaginal sex within the 3 months before Screening (per self-report)
• •Negative pregnancy test at Screening and Enrollment.
• •Does not intend to become pregnant within the next 12 months.
• •Willing to use COCs for at least 48 weeks as their method of contraception.
• •HIV negative at Screening and Enrollment.
• •Willing to use oral PrEP for at least 48 weeks.
• •Hepatitis B (HBV) surface antigen (HbsAg) negative per blood test at Screening.
• •Hepatitis C (HCV) negative at Screening.
• •Normal estimated creatinine clearance (eCrCl) ≥ 60 ml/min per blood test at Screening.