Effects of Long Duration Cycling in People With Type 1 Diabetes

Exclusion Criteria

• •Unable to ride gravel bikes.
• •Unable to use clipless pedals.
• •Pregnancy and breastfeeding.
• •Hypoglycemia unawareness (Clarke Test \> 3).
• •Severe hypoglycemia in the previous 6 monhts.
• •Progressive fatal disease.
• •History of drug or alcohol abuse.
• •Impaired liver function.
• •Clinically relevant microvascular complications (macroalbuminuria, pre-proliferative and proliferative retinopathy), cardiovascular, hepatic, neurological, endocrine or other systemic disease, apart from T1D.
• •Mental conditions that prevent the subject from understanding the nature, purpose and possible consequences of the study.
• •Using an experimental drug or device during the prior 30 days.
• •Inclusion (healthy control group): adults 18-60 years without diabetes and physically active (≥ 4 hours/week of exercise) who can provide pre/post saliva and uringe samples for omics analyses.