Trial of ONC-PluReceptor NK Cells With Epcoritamab and Tafasitamab for Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma

Primary Objective: To establish the safety and recommended phase II dose (RP2D) of umbilical cord blood (CB)- derived natural killer (NK) cells transduced with ONC-PluReceptor (CD3 complex/IL-15) in combination with epcoritamab and tafasitamab for patients with relapsed/refractory (R/R) CD19/CD20-positive B-cell non-Hodgkin lymphomas. Secondary Objectives: 1. To evaluate the overall response rate (ORR), complete response (CR) rate and partial response (PR) rate of patients treated at the RP2D. 2. To evaluate the duration of response (DOR). 3. To evaluate the progression-free survival (PFS) rate. 4. To evaluate the overall survival (OS) time. 5. To quantify the persistence of infused donor NK cells in the recipient. 6. To conduct comprehensive immune reconstitution studies.