This study is a prospective cohort study designed to assess the validity, feasibility, and clinical utility of a topographic classification system for placenta accreta spectrum (PAS), with a primary focus on its application in the actual execution of surgery. This study is investigating a clinical decision flowchart used for intraoperative staging and classification of placenta accreta spectrum (PAS) or similar uterine surgical scenarios. It integrates topographic classification, surgical decision-making, and treatment strategy selection.
The classification system will directly guide and be integrated into real-time surgical planning and management-from cesarean hysterectomy to one-step conservative surgery-based on prenatal ultrasound staging and intraoperative findings.
* Standardizing prenatal ultrasound staging for PAS.
* Implementing a structured protocol for intraoperative classification and surgical execution according to ultrasound.
* Collecting and correlating surgical and pathological findings, including intraoperative photos, videos, and gross and histological analysis.
* Utilizing an objective method to quantify intraoperative blood loss.
* Comparing preoperative ultrasound findings with intraoperative and postoperative data to validate the classification system.
* Managing participant dropouts and protocol deviations to ensure data integrity and minimize bias.
* Applying appropriate statistical adjustments for multiple group comparisons to reduce the risk of type I error. Methods such as Bonferroni correction or false discovery rate adjustments will be utilized where applicable.
* Incorporating serial blood draws for plasma and whole blood analysis to identify potential biomarkers associated with PAS severity, surgical complexity, and clinical outcomes. This will be optional and stored in the biorepository.
