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A Phase 1B, Open-label, Multicenter Study to Evaluate the Safety and Preliminary Efficacy of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects
The main purpose of the study is to understand the safety and tolerability of cemsidomide when given along with elranatamab in subjects with relapsed or refractory multiple myeloma. The first part of the study will evaluate different dose levels of cemsidomide in combination with elranatamab in a limited number of subjects. Approximately 3 different dose levels of cemsidomide in combination with elranatamab may be explored. Once a dose level is determined safe, additional subjects may be enrolled through expansion of the dose level. This expansion will provide further exploration of the safety and evaluation of preliminary antimyeloma activity. Cemsidomide will be taken orally each cycle for 14 days on/14 days off (1 cycle=28 days). Elranatamab will be administered by subcutaneous injection twice a month. Dexamethasone will be administered weekly until a confirmed response but no longer than 4 cycles.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Banner MD Anderson Cancer Center
Gilbert, Arizona, United States
UCLA Health, Jonsson Comprehensive Cancer Center
Santa Monica, California, United States
Tampa General Hospital
Tampa, Florida, United States
Winship Cancer Institute, Emory University
Atlanta, Georgia, United States
Loyola University Medical Center
Maywood, Illinois, United States
Indiana University
Indianapolis, Indiana, United States
Norton Cancer Institute St. Matthews
Louisville, Kentucky, United States
University of Maryland Greenbaum Comprehensive Cancer Center
Baltimore, Maryland, United States
START Midwest
Grand Rapids, Michigan, United States
University of Nebraska
Omaha, Nebraska, United States
Start Date
February 6, 2026
Primary Completion Date
December 1, 2028
Completion Date
June 1, 2029
Last Updated
March 5, 2026
60
ESTIMATED participants
Cemsidomide
DRUG
Elranatamab
BIOLOGICAL
Lead Sponsor
C4 Therapeutics, Inc.
NCT07333430
NCT06767254
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT02203643