Improving Chemotherapy Induced Peripheral Neuropathy in Children With Leukemia: A Study of Transcutaneous Acupoints Electrical Stimulation and Auricular Acupressure Interventions

Exclusion Criteria

• •receiving multiple cancer treatment
• •had a diagnosis of cancer in the central nervous system cancer, cancer relapse or secondary cancer
• •having other neuromuscular disorders, for example, traumatic brain injury and cerebral palsy
• •having other systematic diseases that cause toxicity in the peripheral nervous system, such as sickle cell disease (SCD), Guillain-Barre ́ Syndrome (GBS), anterior cutaneous nerve entrapment syndrome (ACNES), obstetric brachial plexus injury (OBPI), type I diabetes mellitus, postherpetic neuralgia (PHN), peroneal nerve injury, and reflex sympathetic dystrophy (RSD)
• •acupoints areas with injuries, wounds or allodynia
• •participated in any other CIPN non-pharmacological intervention programme
• •having any impaired bone marrow suppression, liver or renal function
• •contraindications to TEAS or auricular acupressure: such as having a pacemaker, skin infection, damage, or allergy to the electrodes
• •suffering from mental illness or using antipsychotic drugs
• •parents and children refused to give consent.