Effectiveness of mRNA-1273 Variant-Containing Vaccine Formulation Against Severe Outcomes in Adults Aged 50-64 Years Without Risk Factors for Severe COVID-19

Exclusion Criteria

• •Medical conditions that increase the risk of severe COVID-19, which will be assessed through self-reporting. These medical conditions include:
• •1. Asthma
• •2. Cancer (excluding non-melanoma skin cancer)
• •3. Cardiomyopathies
• •4. Cerebrovascular disease
• •5. Chronic kidney disease
• •6. Chronic lung disease
• •7. Cystic Fibrosis
• •8. Dementia
• •9. Diabetes
• •10. Down syndrome
• •11. Heart failure
• •12. Human Immunodeficiency Virus
• •13. Immunosuppressive therapy
• •14. Ischemic heart disease
• •15. Liver disease
• •16. Neurological/neuromuscular disease
• •17. Psychiatric disease (psychotic, schizophrenic, schizotypal, depressive, and bipolar (affective) disorders).
• •18. Severe obesity (body mass index \>35 kg/m2)
• •19. Severe substance abuse
• •20. Short bowel syndrome
• •21. Solid organ transplant or hematological transplant