The Effect of Reversal of Remimazolam Sedation With Flumazenil on Cognitive Function in Patients Undergoing Hip Arthroplasty Under Spinal Anesthesia

Exclusion Criteria

• •Known hypersensitivity or allergy to benzodiazepines, flumazenil, local anesthetics
• •Contraindications to spinal anesthesia or patient refusal of this anesthesia technique.
• •Severe liver dysfunction.
• •History of epilepsy or seizures
• •Chronic (daily use for \> 2 weeks in the last 3 months) use of benzodiazepines or non-benzodiazepine hypnotics (so-called "Z" drugs: zolpidem, zopiclone, zaleplon).
• •Alcohol abuse defined as regular consumption of more than: in men: 40 g of pure ethanol at a time; in women: 20 g of pure ethanol at a time, or a history of psychoactive substance dependence.
• •Planned revision hip arthroplasty or bilateral surgery.
• •Significant neurological or psychiatric diseases that may affect the assessment of cognitive function.
• •The need for sedative premedication.