Evaluation of Efficacy of Minimally Invasive Local Therapy for Lung Tumors and Its Impact on Breathing Function

Lung cancer remains one of the leading causes of cancer-related death worldwide, and the lungs are also a common site of metastases from other cancers such as colorectal, breast, or kidney tumors. While surgery is considered the gold standard for treatment of early-stage lung cancer and resectable pulmonary metastases, many patients are not suitable surgical candidates due to age, comorbidities, or personal choice. For these patients, less invasive treatments such as stereotactic body radiotherapy (SBRT) or image-guided thermal ablation may provide effective alternatives. This study is designed to evaluate the safety, effectiveness, and patient-centered outcomes of three treatment strategies for malignant lung tumors: * Surgery (anatomical lung resection, when feasible) * Stereotactic body radiotherapy (SBRT), which delivers high doses of precisely targeted radiation * Minimally invasive thermal ablation, performed under CT guidance using microwave or cryoablation technology to destroy tumor tissue with heat or freezing Thermal ablation and SBRT are established treatment options in many centers worldwide, but there is limited prospective data directly comparing these modalities with surgery. This trial aims to address that gap by examining not only oncologic outcomes such as recurrence, survival, and complications, but also functional and quality-of-life outcomes. Study Objectives: * To compare disease control (local, regional, and distant recurrence) and survival outcomes across surgery, SBRT, and ablation. * To evaluate complication rates and hospitalization needs after each treatment. * To assess the effect of each treatment on respiratory function using spirometry, gas diffusion testing, and lung perfusion scintigraphy. * To monitor health-related quality of life (HRQoL) using the SF-36 questionnaire before and after treatment. Study Design: This is a prospective, single-center, non-randomized study conducted at the Lithuanian University of Health Sciences Kaunas Clinics. Eligible patients are adults (≥18 years) with either primary peripheral lung cancer or oligometastatic pulmonary disease (≤5 lesions, each ≤3 cm in size), who are suitable for surgery, SBRT, or thermal ablation based on multidisciplinary team (MDT) assessment. Patients are assigned to one of the three treatment groups-surgery, SBRT, or ablation-based on clinical suitability and shared decision-making between the MDT and the patient. Follow-Up Procedures: Participants are followed for up to 24 months with scheduled visits and investigations, including: * Clinical assessments at baseline, 1, 3, 6, 12, 18, and 24 months * Chest CT scans at baseline and 1, 3, 6, 12, 18, and 24 months after the treatment * FDG-PET/CT if clinically indicated * Spirometry and gas diffusion testing at baseline, 3 months, and 6 months * Lung perfusion scintigraphy at baseline and 3 months * Blood sampling (up to 10 ml) at baseline, 3 months, and 6 months * Completion of quality-of-life questionnaires at baseline and one month after treatment Risks and Benefits: Risks include discomfort from diagnostic procedures (blood draws, imaging, spirometry), possible treatment-related complications such as pneumothorax after ablation, infection or post-operative pain after surgery, and radiation-related side effects (e.g., radiation pneumonitis, infection) after SBRT. However, all procedures are well-established in clinical practice, and serious complications are rare. Benefits include close monitoring of disease status with imaging, which may enable early detection of recurrence and timely treatment. Patients may also benefit from comprehensive functional assessments that can guide future care. Expected Outcomes: This study is expected to provide comparative information on the safety, effectiveness, and impact on quality of life of surgery, stereotactic body radiotherapy, and minimally invasive thermal ablation in patients with malignant lung tumors. By evaluating recurrence, survival, complications, and respiratory function, the study aims to identify which patients benefit most from each treatment approach and to support more personalized treatment planning in the future. Sample Size and Duration: The study aims to enroll approximately 100 participants in Lithuania. Each participant will be followed for two years after treatment. Significance: This study is expected to provide valuable evidence on the comparative effectiveness of surgery, SBRT, and thermal ablation in the management of malignant pulmonary tumors. By integrating oncologic, functional, and quality-of-life outcomes, the study seeks to support personalized medicine approaches and improve decision-making in multidisciplinary care of lung cancer and metastases.