1. Having a current or past diagnosis of bipolar disorder or psychotic disorders.

2. Having a moderate to severe substance use disorder within the past six months.

3. Having active suicidal ideation.

4. Having a neurocognitive disorder.

5. Having an unstable or decompensated medical illness likely to confound study outcomes.

6. Being pregnant or lactating.

7. Having known contraindications to the indicated antidepressant classes.

8. Being unable to provide informed consent.

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BIOMARKERS FOR DRUG SELECTION IN DEPRESSION