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Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration | Clinical Trials | Clareo Health

RECRUITINGPHASE3

Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration

Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration (SERENE)

NCT07269808•Massachusetts General Hospital

Summary

This study is a pragmatic, randomized controlled pilot trial comparing remimazolam with propofol for endoscopic procedures, designed to assess the feasibility and clinical outcomes associated with implementing a pragmatic randomized trial of sedation practices in the endoscopy setting.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Aged 18 years of age or older
•Planned endoscopic procedure
•American Society of Anesthesiologists (ASA) Physical Status I to III

Exclusion Criteria

•Planned tracheal intubation
•Procedure length anticipated to exceed 45 minutes
•Previously participated in the trial
•Pregnant (defined as a positive test using pre-procedural clinical testing performed as part of their routine care) or breastfeeding
•Allergy or hypersensitivity to one of the study medications
•Blind, deaf, or unable to communicate in English
•Co-enrollment in other interventional studies that, in the opinion of the site investigator and/or their delegate, might interfere with study participation, collection, or interpretation of the study data

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Key Dates

Start Date

March 3, 2026

Primary Completion Date

June 1, 2026

Completion Date

June 1, 2026

Last Updated

March 5, 2026

Enrollment

100

ESTIMATED participants

Conditions

AnesthesiaSedationEndoscopy

Interventions

Remimazolam

DRUG

Propofol

DRUG

Contacts

Oluwaseun Johnson-Akeju, MD

CONTACT

617-726-3030 oluwaseun.akeju@mgh.harvard.edu

Ariel Mueller, MA

CONTACT

6177269252 almueller@mgh.harvard.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 5, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration

Inclusion Criteria

Exclusion Criteria

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