History of fasting triglyceride levels of ≥500 milligrams per deciliter (mg/dL), based on medical history
Fasting triglyceride level ≥500 mg/dL at two separate visits during screening (at least 7 days apart)
Have a body mass index (BMI) within the range of 18.5 to 45.0 kilograms per square meter (kg/m2) (inclusive)
You may not be if
Have had a major atherosclerotic cardiovascular event within the past 3 months prior to screening
Have a known genetically confirmed diagnosis of Familial Chylomicronemia Syndrome
Have a history of or planned treatment involving any gene editing or gene therapy modalities, including but not limited to CRISPR-based, viral vector-mediated, or other genetic modification techniques
Have a history of chronic alcohol abuse within 3 years prior to screening
