Hemodynamic Effects of Inhaled Iloprost in PH-COPD (HOLLYWOOD)

Inclusion Criteria

• •Age 40 years or older.
• •Established diagnosis of severe or very severe Chronic Obstructive Pulmonary Disease (COPD), corresponding to GOLD stage 3 or 4.
• •Symptomatic Group 3 Pulmonary Hypertension (PH) confirmed by Right Heart Catheterization (RHC) with the following hemodynamic profile at rest:
• •Mean Pulmonary Artery Pressure (mPAP) \> 35 mmHg.
• •Pulmonary Vascular Resistance (PVR) \> 5 Wood Units (WU).
• •Pulmonary Capillary Wedge Pressure (PCWP) ≤ 15 mmHg.
• •Capable of providing written informed consent.