Federal University of Health Science of Porto Alegre
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age ≥18 years
Hospitalized with suspected histoplasmosis b
Diagnosis of confirmed or probable histoplasmosis (via positive Histoplasma antigen test, culture, histopathology or microscopy)
Provision of Informed Consent by participant or surrogate c
You may not be if
Previous diagnosis of histoplasmosis
Pregnant persons (all persons who could potentially be pregnant will have a pregnancy test prior to enrollment, and if negative, must agree to contraception for the duration of the study)
Breastfeeding and unable to stop for the duration of the study
Renal impairment (serum creatinine or blood urea nitrogen (BUN) \>2.0x upper limit of normal)
Allergy or contraindication to a study medicine
More than one dose of an amphotericin product in the prior 7 days
Suspected central nervous system involvement of histoplasmosis
Likely to die in the next 48 hours in the judgment of the investigator
Unlikely to follow up for the duration of the study in the judgement of the investigator
Significant drug-drug interaction with itraconazole or posaconazole (such as rifampin in persons with TB)
Current diagnosis of cryptococcosis or leishmaniasis
QTc interval consistently \>450 milliseconds
Prisoners
Unable to take oral medications
Clareo Health | Histoplasmosis Induction and Consolidation Therapy Factorial Randomized Clinical Trial (Histo-FACT)
