Subclinical atherosclerotic CVD (e.g., coronary, cerebrovascular, or peripheral arterial plaque or calcifications on imaging), clinical atherosclerotic CVD (e.g., myocardial infarction or revascularization), or increased risk for atherosclerotic CVD (i.e., \>2 of hypertension, diabetes mellitus, hyperlipidemia, and active smoking)
Ability to understand and sign informed consent
You may not be if
History of stroke, brain surgery, or seizure
Use of certain CVD medications (e.g., beta-blockers, high-intensity statins \[e.g., rosuvastatin 20/40 mg and atorvastatin 40/80 mg\], PCSK-9 inhibitors)
Psychiatric or cardiovascular medication change within 4 weeks (i.e., stable regimen is allowed)
Unstable blood pressure or cardiac arrhythmia
Currently in a supervised or graduated exercise program
Neurological or systemic inflammatory disease/current systemic anti-inflammatory therapy
Moderate/severe alcohol/substance use disorder
Current mania/psychosis
Weight \>300 lbs.
Claustrophobia
Pregnancy
Metal implants
Uncontrolled hyperglycemia (HgbA1c\>7.5%)
Subjects who have had significant radiation exposure as part of research (\>2 nuclear tests, computed tomography images, or fluoroscopic procedures) during the preceding 12-months
