Primary objectives:
To establish the feasibility of a beetroot juice supplement in people living with Alzheimer's disease (primary outcome). To establish whether a twice per day, 1-week beetroot juice intervention will induce changes in dementia related health outcomes (secondary outcomes).
Outline:
Participants will complete a 24-hour food diary prior to baseline testing before starting twice daily supplementation of beetroot juice shots for 7 days. Post-testing will be conducted on day 8 with a further 24-hour food diary having been completed prior to testing.
Age
65–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Aged 65-85 years
Mild or Moderate Alzheimer's disease
Participants must be able to speak, read, and understand English to participate in this study.
To support adherence, participants are asked to have a carer, partner, friend, or family member available to assist with reminders to take the shots twice daily.
You may not be if
Advanced or severe Alzheimer's Disease
Diagnosis of an additional neurological condition
Have used antibiotics in the last month
Use of mouthwash in the last month
Use of medication affecting nitrate metabolism (for example proton pump inhibitors, Isosorbide Mononitrate, Sildenafil or Glyceryl Trinitrate).
