Food Effect Study in Healthy Volunteers

Exclusion Criteria

• •Medical/Surgical History and Mental Health
• •1. Mean QTcF interval greater than 440 msec on triplicate ECGs. Use of prescription or over-the-counter (OTC) medications known to significantly prolong the QT or QTcF interval.
• •2. History of hypertension or untreated hypertension (systolic blood pressure (BP) \>140 mmHg and/or diastolic BP \>90 mmHg).
• •3. Known self or family history (first-degree relative) of multiple endocrine neoplasia Type 1.
• •4. History of stomach or intestinal surgery or resection (except appendectomy, hernia and/or cholecystectomy).
• •Diagnostic assessments.
• •5. Clinically significant abnormal clinical chemistry, hematology, coagulation or urinalysis as judged by the investigator.
• •6. History or evidence of hepatitis C virus (HCV), or hepatitis B virus (HBV) infection or human immunodeficiency virus (HIV) at screening.
• •7. Estimated creatinine clearance (CLcr) of \<90 mL/min.
• •8. AST, ALT or bilirubin \> ULN at screening.
• •9. Prior Study Participation.
• •10. Subjects who have received any IMP in a clinical research study within 5 half-lives or within 30 days prior to first dose.
• •11. Prior and Concomitant Medication.
• •12. Subjects who are taking, or have taken, any prescribed or OTC drug or herbal remedies (other than HRT/hormonal contraception and up to 4 g per day acetaminophen) in the 14 days before first study medication administration.
• •13. Currently dieting (formal weight loss program) and/or are currently using or have used within 2 months of screening any drugs for weight management.
• •14. Received prior menin inhibitor treatment.