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A Prospective Evaluation of Optic Nerve Sheath Diameter Changes Measured by Ultrasonography During Cardiopulmonary Bypass in Patients Undergoing Open Heart Surgery
During cardiopulmonary bypass (CPB) in open-heart surgery, direct measurement of intracranial pressure is not feasible. Evaluation of the optic nerve sheath diameter (ONSD) by ultrasonography is considered a reliable method for predicting increases in intracranial pressure. This study aims to investigate changes in ONSD in patients undergoing open-heart surgery with CPB.
Several mechanisms during CPB-including inflammatory response, hemodilution, reperfusion injury, hypothermia-rewarming imbalances, and microembolism formation-can lead to increased intracranial pressure and cerebral edema. Ultrasonographic measurement of ONSD provides a noninvasive means of monitoring these changes. In this study, ONSD will be measured at different time points, while hemodynamic parameters, NIRS values, and arterial blood gas analyses will be recorded simultaneously. The primary objective is to evaluate changes in ONSD, and the secondary objective is to determine the potential impact of these changes on intracranial pressure.
Age
18 - 85 years
Sex
ALL
Healthy Volunteers
No
Medipol University
Istanbul, Turkey (Türkiye)
Start Date
June 10, 2025
Primary Completion Date
October 10, 2025
Completion Date
November 25, 2025
Last Updated
November 28, 2025
40
ACTUAL participants
Ultrasonography of the Optic Nerve Sheath
PROCEDURE
Lead Sponsor
Medipol University
NCT06984276
NCT06979999
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