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Impact of Dietary Guidelines Diets Containing Mostly Ultra-Processed Foods Compared to Less-Processed Foods on Biomarkers of Cardiometabolic Disease
The purpose of this research is to test how processing food can affect how one's body responds to it.
The purpose of this project is to address the current gap in research on ultra-processed foods (UPFs) and cardiometabolic health with a feeding study that addresses the limitations of previously conducted intervention studies in matching UPF- and unprocessed- foods intervention diets for diet quality, nutrient content, and food type. Therefore, the primary objective is to evaluate diets composed primarily of ultra-processed or less processed foods that meet dietary guidelines recommendations on chronic disease risk factors. More specifically, when Dietary Guidelines for Americans (DGA)-compliant diets comprised of mostly ultra-processed and unprocessed foods (per Nova) are fed to generally healthy participants, determine whether there is an impact on: * blood pressure * fasting glucose and insulin concentrations, or * lipid panel (total cholesterol, HDL-C, LDL-C, triglycerides).
Age
18 - 65 years
Sex
ALL
Healthy Volunteers
Yes
USDA Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States
Start Date
January 1, 2026
Primary Completion Date
December 1, 2029
Completion Date
December 1, 2029
Last Updated
November 26, 2025
79
ESTIMATED participants
Low-processed DGA Diet
OTHER
Ultra-processed DGA Diet
OTHER
Lead Sponsor
USDA Grand Forks Human Nutrition Research Center
NCT07445503
NCT07443059
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT07342855