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Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery

A Randomized, Parallel, Open-label With Blinded Assessment Study Comparing Hemodynamic Profiles Between Remimazolam- and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Robot-assisted Gynecologic Surgery

NCT07251101•Ilsan Cha hospital

View on ClinicalTrials.gov

Summary

This single-center study at CHA Ilsan Medical Center compares intraoperative hemodynamics between remimazolam- and propofol-based total intravenous anesthesia (TIVA) in patients undergoing robot-assisted gynecologic surgery requiring pneumoperitoneum and steep Trendelenburg positioning.

Detailed Description

This study aims to compare intraoperative hemodynamic characteristics between remimazolam- and propofol-based total intravenous anesthesia (TIVA) in patients undergoing robot-assisted gynecologic surgery. Continuous invasive blood pressurewill be analyzed to evaluate time-weighted average (TWA) and area-under-the-curve (AUC) differences between groups. The study is designed as a randomized, parallel, open-label with blinded assessment trial.

Eligibility

Age

0 - 65 years

Sex

FEMALE

Healthy Volunteers

Inclusion Criteria

•Female patients \<65 years of age
•American Society of Anesthesiologists (ASA) physical status I-II
•Scheduled to undergo robotic hysterectomy under general anesthesia

Exclusion Criteria

•Body mass index (BMI) \> 35 kg/m²
•Baseline hypotension (systolic blood pressure \<100 mmHg) or bradycardia (heart rate \<60 bpm)
•History of ischemic heart disease or cardiac conduction block
•Significant cardiopulmonary disease, including hypoxemia (SpO₂ \<90%), uncontrolled asthma, or chronic obstructive pulmonary disease (COPD)
•Use of inhalational anesthetics during anesthesia
•Conversion from robotic/laparoscopic surgery to open laparotomy

Locations (2)

CHA Ilsan Medical Center

Goyang-si, Gyeonggi-do, South Korea

CHA Ilsan Medical Center

Goyang-si, South Korea

Key Dates

Start Date

January 2, 2026

Primary Completion Date

March 31, 2027

Completion Date

September 30, 2027

Last Updated

November 26, 2025

Enrollment

ESTIMATED participants

Conditions

Anesthesia, IntravenousHemodynamic StabilityGynecologic Surgery

Interventions

Remimazolam

DRUG

Propofol

DRUG

Contacts

Joohyun Lee Assistant Professor, Dept. of Anesthesiology and Pain Medicine, MD

CONTACT

+82-31-782-8415 hightothesky1004@gmail.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 26, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery

Inclusion Criteria

Exclusion Criteria

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