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Ozone Therapy for the Treatment of Oral Mucositis in Patients Undergoing Radio and Chemotherapy in the Head and Neck Region

Ozone Therapy for the Treatment of Oral Mucositis in Patients Undergoing Radio and Chemotherapy in the Head and Neck Region: Retrospective Observational Study

NCT07247799•Andrea Scribante

View on ClinicalTrials.gov

Summary

The present study aims to evaluate the effectiveness of a combined protocol of professional and at-home ozone therapy in the treatment of oral mucositis in patients undergoing radio- and/or chemotherapy. In-office treatment was performed using a medical ozone generator, while at-home therapy involved the daily application of high-concentration ozonated oil products. The study assessed the reduction in mucositis severity (WHO scale), decrease in pain (VAS scale), and improvement in patient-reported quality of life, with specific attention to nutrition, oral hygiene, and treatment adherence.

Eligibility

Age

40 - 85 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•patients undergoing radio and chemotherapy for head and neck cancer and cancers in other districts

Exclusion Criteria

•syndromic patients
•pregnant women
•patients with cardiac pacemakers
•epileptic patients
•patients with high sensitivity to electric current

Locations (1)

Unit of Dental Hygiene - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia

Pavia, Lombardy, Italy

Key Dates

Start Date

September 1, 2025

Primary Completion Date

January 10, 2026

Completion Date

January 20, 2026

Last Updated

January 27, 2026

Enrollment

ACTUAL participants

Conditions

Oral MucositisHead and Neck Neoplasms

Interventions

Ozone treatment

DEVICE

Prevention of Oral Mucositis in Head and Neck Cancer.

NCT05853692

Oral Mucositis

View study

RECRUITINGPHASE2

Spirulina-Derived Product Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors

NCT07040969

Radiation-induced Oral Mucositis

View study

RECRUITINGPHASE3

Head and Neck Cancer Study Project in the Geriatric Population

NCT06998069

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 27, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Ozone Therapy for the Treatment of Oral Mucositis in Patients Undergoing Radio and Chemotherapy in the Head and Neck Region

Inclusion Criteria

Exclusion Criteria

Prevention of Oral Mucositis in Head and Neck Cancer.

Spirulina-Derived Product Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors

Head and Neck Cancer Study Project in the Geriatric Population

Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC

NIDCD Otolaryngology Clinical Protocol Biospecimen Bank

Correlation and Predictive Research of Metal Elements in Radiation-Induced Oral Mucositis