Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care

Exclusion Criteria

• •Patient previously included in the study during a previous stay
• •Injection of iodinated contrast medium outside the scope of the study within 24 hours prior to inclusion, or scheduled within 9 hours following the scheduled time of iohexol injection
• •Contraindication to iohexol: known or suspected immediate or delayed hypersensitivity, thyrotoxicosis.
• •Patient undergoing morphine treatment or substitution treatment such as methadone or buprenorphine prior to hospitalization (having received morphine or a derivative regardless of the route of administration in the week prior to hospitalization).
• •Chronic liver disease likely to interfere with morphine metabolism (cirrhosis )
• •Any condition that contraindicates the use of morphine according to the summary of product characteristics
• •Patients under legal protection
• •Pregnant or breastfeeding women
• •Need for extrarenal epuration within 24 hours of inclusion