Mesenchymal Stem Cells for Chronic Kidney Diseases

Exclusion Criteria

• •Extremely severe anemia (hemoglobin \< 30 g/L)
• •Received blood product transfusion therapy within 1 month
• •Autosomal dominant or recessive polycystic kidney disease (ADPKD)
• •History of kidney transplant or other solid organ transplant
• •Active systemic or localized infection (e.g., pneumonia, osteomyelitis)
• •Allergy to stem cells themselves or stem cell-related culture medium
• •History of allergic reaction to cell products (e.g., blood transfusion, platelets)
• •History of coagulation disorders (thromboembolism, pulmonary embolism, deep vein thrombosis)
• •History of malignancy or current malignant disease
• •Elevated tumor markers (AFP, CEA, CA199, CA125, etc.)
• •Pregnant women or women with plans for pregnancy within 3 months after MSC therapy
• •Participation in drug-related clinical trials within the past 2 months
• •Any form of drug abuse, mental illness, or other conditions considered by the investigator as potentially affecting the trial's validity or the subject's health