Firstline Sequential AG and mFOLFOX Combined With Serplulimab and Bevacizumab Versus AG Chemotherapy Alone in Advanced Pancreatic Cancer

This is a randomized, open-label, multicenter, Phase III clinical trial designed to evaluate the efficacy and safety of first-line treatment with Sequential AG (Nab-paclitaxel/Gemcitabine) and mFOLFOX chemotherapy combined with Serplulimab and Bevacizumab, versus AG chemotherapy alone, in patients with previously untreated, unresectable, locally advanced, or metastatic pancreatic ductal adenocarcinoma. Approximately 292 eligible subjects will be randomized in a 1:1 ratio to receive either the experimental combination or the standard chemotherapy control. Treatment will continue until disease progression, unacceptable toxicity, withdrawal of consent, or study termination, with the primary endpoint being Overall Survival (OS) and key secondary endpoints including Progression-Free Survival (PFS), Objective Response Rate (ORR), and safety.