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Effectiveness of Hyaluronic Acid (hyaDENT BG® Gel) Compared With Enamel Matrix Proteins (Emdogain®) in the Treatment of Angular Bone Defects in Combination With a Xenograft (Bio-Oss Collagen®) | Clinical Trials | Clareo Health

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Effectiveness of Hyaluronic Acid (hyaDENT BG® Gel) Compared With Enamel Matrix Proteins (Emdogain®) in the Treatment of Angular Bone Defects in Combination With a Xenograft (Bio-Oss Collagen®)

NCT07230522•Medical University of Sofia

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn whether hyaluronic acid (HyaDent® BG) provides similar benefits to Emdogain® when both are used with Bio-Oss® Collagen during periodontal surgery in adults with periodontal (intrabony) defects. The main questions it aims to answer are: Does the treatment reduce probing pocket depth? Does the treatment increase clinical attachment level? Does the treatment increase radiographic bone fill? Does the treatment change the gingival margin position? Researchers will compare Bio-Oss Collagen + HyaDent BG with Bio-Oss Collagen + Emdogain to see whether HyaDent BG achieves similar improvements in clinical and radiographic outcomes as Emdogain. Participants will: Undergo periodontal surgery to treat the vertical bone defect(s), with either Bio-Oss Collagen + HyaDent BG or Bio-Oss Collagen + Emdogain. Attend follow-up visits for periodontal measurements and radiographs.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Adults over the age of 18 diagnosed with periodontal disease-Stage III or IV periodontitis;
•* Sites with bone defects and a probing pocket depth (PPD) ≥ 6 mm, accompa-nied by bleeding on probing (BoP) at re-evaluation, conducted six weeks after non-surgical periodontal therapy;
•* Full Mouth Plaque Score (FMPS) \< 20% and Full Mouth Bleeding Score (FMBS) \< 15% prior to surgical treatment;
•* Good general health with no systemic conditions and no known allergies to materials or medications used in the study.

Exclusion Criteria

•Medical conditions contraindicating surgical intervention;
•* Pregnancy or lactation;
•* Heavy smokers;
•* Untreated periodontal disease;
•* Poor oral hygiene;
•* Acute infectious lesions in the area of intervention;

Locations (1)

Departement of Periodontology, Faculty of Dental Medicine, Medical University of Sofia

Sofia, Bulgaria

Key Dates

Start Date

March 12, 2024

Primary Completion Date

July 31, 2024

Completion Date

January 10, 2025

Last Updated

November 17, 2025

Enrollment

ACTUAL participants

Conditions

PeriodontitisIntrabony Periodontal DefectPeriodontal Bone Loss

Interventions

Bio-Oss Collagen + HyaDent BG

BIOLOGICAL

Bio-Oss Collagen + Emdogain

BIOLOGICAL

Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis

NCT07466966

Peri-implantitisPeriodontitis+1 more

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RECRUITING

Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France

NCT07297836

Pulpitis - IrreversiblePulp Necrosis+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 17, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Effectiveness of Hyaluronic Acid (hyaDENT BG® Gel) Compared With Enamel Matrix Proteins (Emdogain®) in the Treatment of Angular Bone Defects in Combination With a Xenograft (Bio-Oss Collagen®)

Inclusion Criteria

Exclusion Criteria

Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis

Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France

Periodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment

Association of Periodontal Status and Smoking With Salivary Inflammasome Markers

Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management

Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy