The Efficacy and Safety of Pregabalin Combined With Dexmedetomidine in Patients With Fibromyalgia

Inclusion Criteria

• •Diagnosed with FM according to the 2016 Revisions to the 2010/2011 FM diagnostic criteria;
• •Aged 18 years or older;
• •Experiencing moderate to severe FM that have not been effectively alleviated by non-pharmacological treatments and has not received currently recommended pharmacological treatment for FM;
• •Numeric rating scale (NRS) score ≥ 4 at baseline;
• •Aspartate aminotransferase and alanine aminotransferase levels less than twice the upper limit of normal;
• •Estimated glomerular filtration rate of 30 mL/min per 1.73 m2 or higher;
• •Willing to sign the informed consent form and possessing sufficient cognitive and language abilities to comply with all the study requirements.