Age

19–any

Sex

ALL

Healthy volunteers

Not accepted

Males or females ≥19 years of age at time of consent
Body weight \< 90kg
Have a diagnosis of RA per the 2010 ACR/EULAR criteria for at least 6 months
Disease activity of rheumatoid arthritis has been stable for at least 4 weeks prior to randomization (DAS28-CRP ≤ 3.2)
The patient has been taking a stable dose of prednisolone equivalent ≤ 5 mg/day for at least 12 weeks prior to randomization
The dose of corticosteroids has not changed during the 4 weeks prior to randomization

History of major surgery within 8 weeks prior to screening
Increase in the dose of antirheumatic drugs within 4 weeks prior to screening due to worsening arthritis
Pregnant or breastfeeding
RA functional class IV, requiring confinement to bed or wheelchair
History of primary or secondary adrenal insufficiency

Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis