Histologically or cytologically documented metastatic or locally advanced solid tumors including: Head and Neck Squamous Cell Carcinoma, Non-small Cell Lung Cancer, Esophageal/Gastric Cancer, Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Cervical Cancer, Endometrial Cancer, and Urothelial Carcinoma
Age 18 years or older
Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1
Received all appropriate systemic therapies that are locally available for which they are eligible. For Parts 1A and 1C, there is no limit on the number of prior therapies. For Part 1B only, up to 3 prior therapies are allowed, except for NSCLC participants with genomic alterations, who may have up to 4 prior therapies
Availability of tumor tissue
Measurable disease per RECIST 1.1
Adequate organ function
Participants receiving anticoagulants must be on a stable dose
You may not be if
Eye disorders
Untreated brain metastases
Pre-existing clinically significant ocular disorders, active interstitial lung disease, clinically significant cardiac or cerebrovascular disease, or other significant concurrent, uncontrolled medical condition
Previous solid organ or bone marrow transplantation
Concurrent participation in another therapeutic treatment trial
