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Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules | Clinical Trials | Clareo Health

NOT_YET_RECRUITING

Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

NCT07226804•M.D. Anderson Cancer Center

View on ClinicalTrials.gov

Summary

To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.

Detailed Description

Primary Objectives • To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care Secondary Objectives * To determine changes in health-related quality of life changes following ultrasound-guided nsPFA * To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA. * To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Eligibility Criteria
•Scheduled to undergo ultrasound guided nsPFA as standard of care
•Age 18 to 80 years.
•Capable of providing independent consent.
•Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:
•* Benign FNA X 2 or
•* Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
•* Benign FNA X 1 and radiographic/laboratory evidence of functional nature
•Nodule measuring \>2cm in greatest dimension
•Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
+1 more criteria

Exclusion Criteria

•Age \<18
•Patients considered unsuitable for nsPFA by the treating physician

Locations (1)

MD Anderson Cancer Center

Houston, Texas, United States

Key Dates

Start Date

April 26, 2026

Primary Completion Date

August 31, 2028

Completion Date

August 31, 2030

Last Updated

November 10, 2025

Enrollment

ESTIMATED participants

Conditions

Thyroid NodulesPulsed Field Ablation

Interventions

Questionnaire

OTHER

Contacts

Victoria E Banuchi, MD

CONTACT

346-217-8668 vebanuchi@mdanderson.org

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 10, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

Inclusion Criteria

Exclusion Criteria

Ultrasound and Cytological Evaluation 3 Years After Radiofrequency Thermal Ablation of Benign Thyroid Nodules : a Prospective Exploratory Cohort of 180 Nodules

PULSE PVC Registry: Multicenter Study on Focal Pulsed Field Ablation for Premature Ventricular Contractions

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