American Society of Anesthesiologists (ASA) class II-IV
Presenting for major elective, non-cardiac surgery on the colorectal, emergency general surgery, urology, ventral hernia, surgical oncology, or spine services on a weekday
First surgery in the study period (if a patient has multiple surgeries, only the first will be included)
You may not be if
ASA class \>IV
Emergent procedures
Allergy or any contraindication to lidocaine infusion
Patient refusal
Unable to receive or refusal to receive a regional nerve block
Patients who receive an epidural due to standard of care
Direct transfer from operating room to ICU with endotracheal tube in place
Treating team determines patient ineligible prior to study drug administration
Same day surgery
Pregnancy (all female patient of child-bearing age will undergo a pregnancy test the day of surgery)
