Adults aged greater than or equal to (\>=) 18 years on the day of signing the informed consent form.
Confirmed diagnosis of SCD of any genotype.
Experienced 1 to 12 VOCs requiring a visit to a medical facility and treatment with parenteral opioids or a parenteral nonsteroidal anti-inflammatory drug within the 12 months before Screening.
HU Regimen:
a. On stable and well-tolerated Hydroxyurea (HU) regimen for at least 30 days before Screening.
or
b. HU was discontinued or refused (eg, due to concern of side effects or lack of effect).
You may not be if
Absolute neutrophil count less than (\<) 2.5 ×10\^9 cells/Litre at Screening or Baseline (Week 1 Day 1).
If on SCD preventive medication, dose is not stable in the 30 days before Screening.
Clareo Health | Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
