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TRITON-PN: A Phase 3, Global, Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy (hATTR-PN)
The purpose of this study is to: * Determine the efficacy of nucresiran in patients with hATTR-PN by evaluating the effect on neurologic impairment, quality of life, nutritional status, disability, and gait speed * Demonstrate superiority of nucresiran compared to in-study vutrisiran with respect to serum transthyretin (TTR) levels
Age
18 - 85 years
Sex
ALL
Healthy Volunteers
No
Clinical Trial Site
Boston, Massachusetts, United States
Start Date
January 16, 2026
Primary Completion Date
December 27, 2027
Completion Date
June 12, 2031
Last Updated
January 14, 2026
125
ESTIMATED participants
Nucresiran
DRUG
Vutrisiran
DRUG
Lead Sponsor
Alnylam Pharmaceuticals
Data Source & Attribution
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