Patients undergoing primary, unilateral total knee arthroplasty
Ability to provide informed consent
You may not be if
Individuals under the age of 18
Pregnant women
Prisoners
Adults unable to consent
American Society of Anesthesiologists Physical Status score greater than 3
Patients taking any of the following medications before surgery:
Long-acting opioids within 3 days
Any opioids taken within 24 hours
Bupivacaine HCL within 5 days
Chronic opioid use or patients with known or suspected daily use of opioids for seven or more consecutive days within 6 months before their scheduled surgery
Illicit drug use determined by social history
Alcohol abuse determined by a CAGE Substance Abuse Screening Tool Score of at least two or greater
Patients with a known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to any local anesthetic agent of the amide-type, NSAIDs, or to any of the other components of ZYNRELEF
Patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients
Clareo Health | Zynrelef Versus Adductor Canal Block
