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The NoSeal Trial - Nasal Outcome Study Evaluating Artificial Leak-Sealing: A Prospective, Randomized, Controlled, Single-Blinded, Single-Center Clinical Trial Comparing Fibrin Glue (Tisseel®) and a Two-Component Synthetic Polymer Sealant (PEI/PEG, Adherus®) Versus No Sealant for the Prevention of Cerebrospinal Fluid Leak and Promotion of Wound Healing Following Endonasal Skull Base Surgery, Designed in Accordance With the SPIRIT 2025 Guidelines
Conditions
Interventions
Standard multilayer closure without sealant
Fibrin sealant application
+1 more
Locations
1
Poland
Maria Sklodowska-Curie Institute - Oncology Center
Warsaw, Poland
Start Date
August 15, 2025
Primary Completion Date
December 30, 2026
Completion Date
March 15, 2027
Last Updated
October 14, 2025
Lead Sponsor
Maria Sklodowska-Curie National Research Institute of Oncology
Data Source & Attribution
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