A Study to Learn About Study Medicine Called PF-08049820 in People With Eczema

Inclusion Criteria

• •Participants must meet the following criteria:
• •1. Are 18 years of age or older
• •2. Have clinical diagnosis of AD for at least 6 months prior to Day 1 and have diagnosis of AD confirmed by photographs
• •3. Have moderate to severe AD as defined by the following at screening and baseline visits:
• •* Affected body surface area (BSA) greater than or equal to 10% and up to 60%;
• •* Validated Investigator's Global Assessment (vIGA) greater than or equal to 3;
• •* Eczema Area and Severity Index (EASI) greater than or equal to 16;
• •AND
• •-Peak Pruritis Numeric Rating Scale (PP-NRS) greater than or equal to 4 at screening and a weekly average of greater than or equal to 4 at baseline visit
• •4. Do not have a suitable prescribed medicine for AD.
• •5. Body Mass Index (BMI) of 17.5 to 40 kg/m2 and a total body weight greater than 45 kg (100 lbs)