A Study to Investigate the Safety and Efficacy of KQB548 in Participants With Advanced Solid Malignancies

Exclusion Criteria

• •Previous treatment with a KRAS G12D inhibitor or pan-RAS inhibitor
• •History of intestinal disease, uncontrolled inflammatory bowel disease (e.g., Crohn's disease, Ulcerative Colitis), major esophageal or gastric surgery, or other gastrointestinal conditions (e.g., uncontrolled nausea, vomiting, malabsorption syndrome) likely to alter absorption of study intervention or result in inability to swallow oral medications
• •Poorly controlled ascites and/or pleural effusion
• •Requires treatment with a strong and/or moderate CYP3A inhibitor or inducer
• •Requires treatment with a proton-pump inhibitor