Age

18–any

Sex

FEMALE

Healthy volunteers

Not accepted

Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
Have a diagnosis of stress urinary incontinence

Have had urinary incontinence surgery
Have recently received onabotulinumtoxin A (Botox) bladder injections or currently taking medications for urinary incontinence
Have given birth within one year of screening
Have had a change in body weight of more than 11 pounds within 90 days prior to screening
Have used any anti-obesity medication or alternative weight loss remedies within 180 days prior to screening
Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
Have had a cardiovascular health condition within 90 days prior to screening
Are pregnant, intending to be pregnant, breastfeeding, or intending to breastfeed for the duration of the study

A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight