Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging

Exclusion Criteria

• •Pregnancy: Pregnant women are excluded from the study.
• •Inability to Provide Informed Consent:
• •Any participant who refuses to sign the informed consent or is unable to do so due to mental or physical conditions.
• •Refusal of MRI: Individuals who refuse to undergo brain MRI.
• •Contraindications for MRI:Participants with contraindications for MRI exams, such as claustrophobia, metal foreign bodies, pacemakers, or severe kidney failure.
• •Medical Conditions: Known allergy to Dotarem (contrast agent) for neuroinflammatory patients. Individuals with severe renal insufficiency or other conditions that prevent MRI scanning.
• •Cognitive or Psychiatric Issues:
• •Chronic psychiatric conditions, including severe dementia or cognitive dysfunction that could hinder participation.
• •Legal or Institutional Restrictions:
• •Adults under legal protection (e.g., under guardianship or curatorship). Individuals deprived of their liberty.
• •Other Medical Conditions:
• •Individuals with neurological diseases such as ischemic accidents, brain trauma, or encephalitis.
• •Patients on treatments that would interfere with the study, as outlined for each disease.
• •Allergy to Contrast Agent:
• •Allergy to Dotarem for neuroinflammatory patients (MS, NMOSD, etc.).
• •Inability to Adhere to Protocol:
• •Participants who are unable or unwilling to comply with the study protocol.