Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Starting Immunoglobulin (Start Ig)

Exclusion Criteria

• •1. Prior or planned allogeneic haematopoietic stem cell transplantation.
• •2. Already receiving systemic antibiotic prophylaxis for the purpose of preventing bacterial infection (NB: patients may receive antiviral, antifungal and PJP prophylaxis).
• •3. Received immunoglobulin replacement in the preceding three months.
• •4. Objection to receiving immunoglobulin products.
• •5. Known history of IgA deficiency with anti-IgA.
• •6. History of severe allergy to immunoglobulin products.
• •7. Current active infection requiring systemic antibiotics.
• •8. Allergy or intolerance of all domain antibiotic options.
• •9. Pregnant or breastfeeding.
• •10. Severe renal impairment (estimated or measured creatinine clearance of \< 30 mL/min).
• •11. Previous splenectomy.
• •12. Previous participation in this domain.
• •13. Treating team deems enrolment in the domain is not in the best interest of the patient.