1. Subjects with ability to understand the trial procedures and possible adverse events, voluntary participation in the trial.

2. Subjects who can provide written informed consent.

3. Males or females aged 18-55 years (both inclusive).

4. Males with body weight ≥ 50 kg, or females with body weight ≥ 45 kg, body mass index (BMI) 19-28 kg/m2 (both inclusive).

5. No clinically significant abnormalities in the medical history, general physical examinations, vital signs and laboratory tests.

The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of SHR-3045 in Healthy Subjects